کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2793759 1568726 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasma levels of adipokines in systemic lupus erythematosus patients
ترجمه فارسی عنوان
سطوح پلاسماي آديپوكين در بيماران لوپوس اريتماتو سيستميک
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


• Plasma levels of the six adpokines do not differ between SLE and normal controls.
• Omentin-1 level is lower in SLE patients without nephritis.
• Chemerin and cathepsin-S level are higher in SLE with nervous system disorder.

ObjectiveTo evaluate the plasma levels of six adipokines, including chemerin, omentin-1, lipocalin-2, cathepsin-S, cathepsin-L and adipsin, in patients with SLE.MethodsNinety SLE patients and ninety control subjects were recruited, plasma adipokines levels were measured by enzyme-linked immunosorbent assay, and their associations with major clinical and laboratory indexes were analyzed.ResultsThere were no significant differences in plasma chemerin, omentin-1, lipocalin-2, cathepsin-S, cathepsin-L and adipsin levels between SLE patients and controls. Further subgroup analyses by major clinical and laboratory indexes showed that plasma omentin-1 level was significantly lower in SLE patients without nephritis when compared with those patients with nephritis (P = 0.002). Plasma chemerin, cathepsin-S levels in SLE patients without nervous system disorder were significantly lower in comparison with SLE patients with nervous system disorder (P = 0.035, P = 0.029). No significant associations of other adipokines with any major clinical and laboratory indexes were observed.ConclusionsPlasma levels of chemerin, omentin-1, lipocalin-2, cathepsin-S, cathepsin-L and adipsin in SLE patients were not markedly different from the normal controls. The presence of nephritis was connected with higher plasma omentin-1 levels in SLE patients, and the presence of nervous system disorder was associated with higher plasma chemerin, cathepsin-S levels in SLE patients. However, functional studies are awaited to further explore the potential roles of these cytokines in SLE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 86, October 2016, Pages 15–20
نویسندگان
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