کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2802945 | 1568958 | 2012 | 5 صفحه PDF | دانلود رایگان |
BackgroundInsulin-like growth factor I (IGF-I) measurement is widely used for the diagnosis of disorders of GH secretion and sensitivity, and for monitoring of both GH and IGF-I replacement therapies. However, the lack of appropriate reference values obtained from large and representative samples undermines its practical utility.ObjectiveTo establish IGF-I reference values for a commonly used enzyme-labeled chemiluminescent immunometric assay in a large population of children aged 0 to 18 years.DesignCross-sectional analysis of serum IGF-I levels from samples collected in the two major Italian Children's Hospitals.Subjects and methodsIGF-I was measured using a solid-phase, enzyme-labeled chemiluminescent immunometric assay in 24403 children (50.6% girls) aged 0 to 18 years. Quantile regression coupled to multivariable fractional polynomials was used to produce age- and sex-specific reference values.Main outcome measureAge- and sex-specific IGF-I reference values.Results and conclusionReference values for immunometric assay of IGF-I were produced in a large sample of children and adolescents. Prediction equations were provided to automatize their calculations.
Journal: Growth Hormone & IGF Research - Volume 22, Issues 3–4, June–August 2012, Pages 134–138