IGFBP-3 sensitizes prostate cancer cells to interferon-gamma-induced apoptosis

These results demonstrated that in a cancer cell line not responsive to exogenous IGFBP-3 alone, IGFBP-3 sensitized the cells to the anti-proliferative, proapoptotic actions of IFN-γ through an IGF-independent, STAT1- and mTOR-dependent mechanism.