Importance of PPARα for the effects of growth hormone on hepatic lipid and lipoprotein metabolism

Most of the effects of GH on lipid and lipoprotein metabolism were independent of PPARα. However, GH had unique effects on Cyp4a10, DGAT1, and PPARγ2 gene expression in PPARα-null mice showing cross-talk between GH and PPARα signalling in vivo.