کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2808440 | 1157756 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Vitiligo patients present lower plasma levels of α-melanotropin immunoreactivities Vitiligo patients present lower plasma levels of α-melanotropin immunoreactivities](/preview/png/2808440.png)
Vitiligo is a depigmenting disorder characterized by the development of white patches with evidence in favour of an autoimmune mechanism. We investigated the role of melanotropins and the plasma levels of α-melanotropin and ACTH-like immunoreactivities in 40 vitiligo patients with the aim of detecting a possible influence of neuropeptide regulation of immunity. Twenty-one patients had active and 19 had stable vitiligo disease, 16 persons presented with an additional autoimmune thyroid disease.Median α-MSH levels in vitiligo patients were 6.4 pmol/l [5.2;11.3] and significantly lower than in control persons with 11.4 pmol/l [8.6;13.4]. Median ACTH levels of the affected patient group were 17 pg/ml [10.5;28] and appeared statistically higher than 12 pg/ml [7;17] measured in the control group. Measured morning cortisol levels in both groups were not significantly different.Reduced cutaneous α-MSH immunoreactivities have been related to the development of autoimmune-induced depigmenting disorders. Our data present lower α-MSH plasma levels in vitiligo patients which may be associated with the development of vitiligo depigmentation and may indicate a condition of impaired peripheral tolerance in this autoimmune disorder.
Journal: Neuropeptides - Volume 40, Issue 3, June 2006, Pages 177–183