کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2808496 | 1157761 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Leptin facilitates lordosis behavior through GnRH-1 and progestin receptors in estrogen-primed rats Leptin facilitates lordosis behavior through GnRH-1 and progestin receptors in estrogen-primed rats](/preview/png/2808496.png)
Dose response curves for leptin facilitation of estrous behavior (lordosis and proceptivity) were made by infusing the peptide into the lateral ventricle (icv) of ovariectomized (ovx), ad libitum-fed rats injected 40 h previously with 5 μg of estradiol benzoate. Leptin doses of 1 and 3 μg produced significant lordosis quotient at 60 min post-injection, with maximal lordosis being displayed at 120 min. Yet the intensity of lordosis was weak, and a high incidence of rejection behaviors was found. Moreover, leptin did not induce significant proceptive behaviors at any dose. The leptin doses of 1 and 3 μg were selected for determining whether antide, a GnRH-1 receptor antagonist, or the progestin receptor antagonist RU486 could modify the lordosis response to leptin. Icv injection of either antide or RU486 1 h before leptin significantly depressed leptin facilitation of lordosis. The results suggest that leptin stimulates lordosis by releasing GnRH, which in turn activates GnRH-1 and progestin receptors. The physiological role of leptin in the control of estrous behavior remains to be determined.
Journal: Neuropeptides - Volume 45, Issue 1, February 2011, Pages 63–67