Release of calcitonin gene-related peptide from the jugular-nodose ganglion complex in rats - A new model to examine the role of cardiac peptidergic and nitrergic innervation

The present study demonstrates an easily reproducible model for measuring stimulated CGRP release from vagal afferents arising from the JNC. Nitric oxide produced by vagal afferents may stimulate CGRP release upon afferent activation.