کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2808645 1157801 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cholecystokinin enhances GABAergic inhibitory transmission in basolateral amygdala
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Cholecystokinin enhances GABAergic inhibitory transmission in basolateral amygdala
چکیده انگلیسی

The neuropeptide cholecystokinin (CCK) is anxiogenic in studies of human and animal behavior. As the amygdala formation has been implicated in generation of emotional states such as anxiety, we tested the effect of CCK on spontaneous synaptic events in the basolateral amygdala (BLA) using whole cell patch recordings in rat brain slice preparation. We found that CCK increased the frequency of spontaneous inhibitory postsynaptic potentials (sIPSPs) and currents (sIPSCs). This effect was blocked by the fast sodium channel blocker tetrodotoxin (TTX), indicating that the CCK effect is likely mediated by direct excitation of GABAergic interneurons. The CCKB receptor subtype antagonist, CR2945, blocked the CCK effect, while CCK4, a specific CCKB agonist, increased sIPSC frequency. We hypothesize that these actions may underlie the anxiogenic effects of CCK observed in behavioral studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropeptides - Volume 41, Issue 6, December 2007, Pages 453–463
نویسندگان
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