کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2808703 | 1157820 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quetiapine lowers sympathetic and hyperthermic reactions due to cerebral injection of orexin A
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Since no experiment regarding a possible relation between quetiapine and orexin A has been reported in international literature, this experiment tested the effect of quetiapine on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT, colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley rats before an injection of orexin A (1.5Â nmol) into the lateral cerebral ventricle and over a period of 150Â min after the injection. The same variables were monitored in rats with an intraperitoneal administration of quetiapine (5 or 10Â mg/kg bw), injected 30Â min before the orexin administration. The results show that orexin A increases the sympathetic firing rate, IBAT, colonic temperatures and heart rate. This increase is delayed or reduced by the injection of quetiapine. These findings indicate that quetiapine affects the complex reactions related to activation of orexinergic system. Possible influences on the control of body weight and temperature are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropeptides - Volume 40, Issue 5, October 2006, Pages 357-363
Journal: Neuropeptides - Volume 40, Issue 5, October 2006, Pages 357-363
نویسندگان
M. Monda, An. Viggiano, Al. Viggiano, E. Viggiano, G. Messina, D. Tafuri, V. De Luca,