کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2814727 | 1404671 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PRAME is critical for breast cancer growth and metastasis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
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چکیده انگلیسی
Breast cancer is the most common cause of cancer death in women and ranks second among cancer deaths. Metastasis is the main cause of death in breast cancer patients. However, the mechanisms underlying the invasion and metastasis of breast cancer cells remain largely elusive. Here we report that the protein PRAME, a tumor-associated antigen isolated from a melanoma, plays a role in preventing the proliferation and metastasis of breast cancer cells. Knocking down of PRAME promotes breast cancer cell proliferation and inhibits apoptosis. In addition, inhibition of PRAME promotes the invasion of breast cancer cells. To further examine the role of PRAME in vivo, we utilized mouse model and found the volume and the weight of tumors was markedly increased after PRAME was knocked down. This study demonstrates that PRAME functions as a tumor suppressor in breast cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 594, Issue 1, 5 December 2016, Pages 160-164
Journal: Gene - Volume 594, Issue 1, 5 December 2016, Pages 160-164
نویسندگان
Zhengwang Sun, Zhipeng Wu, Fenglin Zhang, Qunfeng Guo, Lin li, Kun li, Hui Chen, Juan Zhao, Dianwen Song, Quan Huang, Lei Li, Jianru Xiao,