Multiple functions of the histone chaperone Jun dimerization protein 2

• JDP2 acts as a transcription factor and histone chaperone.
• JDP2 functions in cell-cycle arrest and cell differentiation.
• JDP2 performs as an oncogene and anti-oncogene.
• JDP2 regulates apoptosis, replicative senescence and -cellular reprogramming.
• JDP2 controls antioxidation and ROS homeostasis.

The Jun dimerization protein 2 (JDP2) is part of the family of stress-responsible transcription factors such as the activation protein-1, and binds the 12-O-tetradecanoylphorbol-13-acetateresponse element and the cAMP response element. It also plays a role as a histone chaperone and participates in diverse processes, such as cell-cycle arrest, cell differentiation, apoptosis, senescence, and metastatic spread, and functions as an oncogene and anti-oncogene, and as a cellular reprogramming factor. However, the molecular mechanisms underlying these multiple functions of JDP2 have not been clarified. This review summarizes the structure and function of JDP2, highlighting the specific role of JDP2 in cellular-stress regulation and prevention.