کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2815227 1159861 2015 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)
چکیده انگلیسی


• The human genome involves six lipoxygenase genes including ALOX15.
• ALOX15 specifically oxygenates phospholipids and biomembranes.
• ALOX15 exhibits a high degree of structural flexibility.
• ALOX15 plays a role in differentiation and in pathogenesis of various diseases.
• Evolutionary change in reaction specificity optimizes membrane oxygenase activity.

Lipoxygenases (LOX) form a family of lipid peroxidizing enzymes, which have been implicated in a number of physiological processes and in the pathogenesis of inflammatory, hyperproliferative and neurodegenerative diseases. They occur in two of the three domains of terrestrial life (bacteria, eucarya) and the human genome involves six functional LOX genes, which encode for six different LOX isoforms. One of these isoforms is ALOX15, which has first been described in rabbits in 1974 as enzyme capable of oxidizing membrane phospholipids during the maturational breakdown of mitochondria in immature red blood cells. During the following decades ALOX15 has extensively been characterized and its biological functions have been studied in a number of cellular in vitro systems as well as in various whole animal disease models. This review is aimed at summarizing the current knowledge on the protein–chemical, molecular biological and enzymatic properties of ALOX15 in various species (human, mouse, rabbit, rat) as well as its implication in cellular physiology and in the pathogenesis of various diseases.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 573, Issue 1, 15 November 2015, Pages 1–32
نویسندگان
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