کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2815229 1159861 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
More heritability probably captured by psoriasis genome-wide association study in Han Chinese
ترجمه فارسی عنوان
بیشتر وراثت پذیری احتمالا توسط مطالعه مرتبط با ژنوم پسوریازیس در هان چینی گرفته شده است
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی


• Missing heritability is a common problem in genome-wide association studies for complex diseases/traits.
• We quantified 45.7% heritability of psoriasis captured by common variants in genome-wide association data.
• The results indicated that the heritability was previously probably underestimated in restricted maximum likelihood analysis.
• Our study highlights that more common variants can be identified by increasing the sample size in psoriasis GWA studies.

Missing heritability is a common problem in genome-wide association studies in complex diseases/traits. To quantify the unbiased heritability estimate, we applied the phenotype correlation-genotype correlation regression in psoriasis genome-wide association data in Han Chinese which comprises 1139 cases and 1132 controls. We estimated that 45.7% heritability of psoriasis in Han Chinese were captured by common variants (s.e. = 12.5%), which reinforced that the majority of psoriasis heritability can be covered by common variants in genome-wide association data (68.2%). The results provided evidence that the heritability covered by psoriasis genome-wide genotyping data was probably underestimated in previous restricted maximum likelihood method. Our study highlights the broad role of common variants in the etiology of psoriasis and sheds light on the possibility to identify more common variants of small effect by increasing the sample size in psoriasis genome-wide association studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 573, Issue 1, 15 November 2015, Pages 46–49
نویسندگان
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