کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2815472 1159872 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computational analyses of the length and compositional variations of the FNBP4 gene across 10 different species
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Computational analyses of the length and compositional variations of the FNBP4 gene across 10 different species
چکیده انگلیسی


• Introns constitute majority of the FNBP4 gene among different species.
• Codon usage pattern of FNBP4 CDS feature species specific deviations.
• Length and base composition of FNBP4 gene varies among different species.
• Codon organization across exons indicates the trend of evolution.

Formin binding protein 4 (FNBP4) interacts with formins and other proteins via its WW domains. Previously, we reported the structural and phylogenetic clustering of FNBP4 across a wide range of organisms from different taxonomic groups along with characterizing its plant variant (Arabidopsis thaliana F4JC80). Recently, the FNBP4 gene is reported to be associated with a congenital disorder Microphthalmia with Limb Anomalies. Except these reports, FNBP4 is mostly uncharacterized, especially the FNBP4 gene. In this context, we have attempted to characterize the FNBP4 gene in terms of its length and compositional variations across 10 different organisms from different taxonomic groups. Our findings highlight that the length of the FNBP4 gene varies greatly among different species. Introns, UTRs and the entire gene were AT rich while CDS and mRNAs were GC rich. The RSCU values were also different for the different organisms indicating a possible impact on translational efficiency of this protein. Comparative analyses highlight gene element and base proportions related characteristics specific to highly expression regulated genes like FNBP4.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 575, Issue 2, Part 3, 10 January 2016, Pages 765–777
نویسندگان
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