The lipoprotein lipase S447X and cholesteryl ester transfer protein rs5882 polymorphisms and their relationship with lipid profile in human serum of obese individuals

• CG + GG genotypes were associated with altered lipid profile in obesity vs. control group.
• Polymorphisms of LPL and CETP were not associated with obesity in our population.
• Association of LPL CG + GG with an increased level of TG, versus CC wild type genotype
• Relationship between CETP GA + AA genotypes and lower level of HDL in obese subjects

BackgroundObesity is often associated with an alter lipid profile, e.g., raised serum triglycerides (TG) and low high-density lipoprotein (HDL) cholesterol levels, both important risk factor for cardiovascular-diseases. The aim of current study was to explore the association of a polymorphism of the lipoprotein lipase (LPL) rs328 and cholesteryl-ester-transfer-protein (CETP) rs5882 genes in relation to lipid profile in subjects with/without obesity.Subjects/methodsGenotyping was carried out in 271 individuals, (151 obese subjects and 120 non-obese). Univariate/multivariate analyses were conducted to evaluate the association of these genetic-polymorphisms with obesity and lipid components.ResultsObese subjects had a significantly (P < 0.05) higher level of triglyceride (TG), blood pressure, waist-circumference and fasting-blood-glucose, and lower level of HDL-C. LPL and CETP polymorphisms were not associated with obesity in our population. However, the LPL rs328-GG-GC genotype was significantly related to a higher concentration of TG, compared to the CC wild-type; and a higher HDL-C level in the obesity-group with respect to the control group. Moreover, obese-subjects carrying the G allele of CETP had a significantly lower level of HDL-C (P < 0.05) compared to those with C allele.ConclusionWe demonstrate a significant association of LPL and CETP polymorphisms with serum triglycerides and HDL-cholesterol.