Maturity onset diabetes of the young (MODY)—History, first case reports and recent advances

• Comprehensive article dealing with MODY history and first case report
• Cammidge (1928) first suggested/claimed the existence of a mild form of familial diabetes.
• Tattersall and Fajans (1974) coined the term MODY.
• R-W (Rinke-Wiegand) pedigree is the classic study in MODY genetics research.
• To-date MODY has subtypes 1–12.

The world is seemingly facing a global increase in people suffering from diabetes especially in developing countries. The worldwide occurrence of diabetes for all age groups in year 2000 was estimated to be 2.8% and this number is most certainly expected to rise to 4.4% by 2030. Maturity-onset of diabetes of the young, or MODY, is a form of monogenic diabetes that is caused by mutations occurring in a number of different genes. Mutations in different genes tend to cause a slightly different variant of diabetes. MODY is typically diagnosed during late childhood, adolescence, or early adulthood and is usually observed to develop in adults during their late 50's. One of the main drawbacks in its diagnosis is that many people with MODY are misdiagnosed as having type 1 or type 2 diabetes. However, a molecular and genetic diagnosis can result in a better treatment and could also help in identifying other family members with MODY. This article explores the historical prospect and the genetic background of MODY, a brief summary of the first case reported and the significant factors that differentiate it from type 1 and type 2 diabetes.