The association between XRCC1 genetic polymorphisms and the risk of endometrial carcinoma in Chinese

• The XRCC1 gene plays an important role in the development of endometrial cancer.
• The c.1161G>A and c.1804C>A are associated with the risk of endometrial cancer.
• The XRCC1 gene contributes to endometrial cancer in Chinese Han populations.

Accumulated evidences report that X-ray repair cross-complementing group 1 gene (XRCC1) genetic polymorphisms play an important role in the development of endometrial carcinoma (EC). This study aims to evaluate the association of XRCC1 c.1161G>A and c.1804C>A genetic polymorphisms with the risk of EC. A total of 218 EC patients and 243 cancer-free controls were included in this study. The genotypes of XRCC1 genetic polymorphisms were determined by the created restriction site-polymerase chain reaction (CRS-PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP) methods. We found that these two genetic polymorphisms were statistically associated with the risk of EC. As for c.1161G>A, in comparison with GG wild genotype, the AA genotype was significantly associated with the increased risk of EC (OR = 2.36, 95% CI 1.28–4.37, χ2 = 7.71, P = 0.005). As for c.1804C>A, the CC genotype significantly increased the risk of EC in comparison with CC wild genotype (OR = 2.77, 95% CI 1.38–5.58, χ2 = 8.54, P = 0.003). Our data indicate that the A allele of c.1161G>A and c.1804C>A genetic polymorphisms could contribute to increase the risk of EC (for c.1161G>A: A versus (vs.) G, OR = 1.34, 95% CI 1.02–1.76, χ2 = 4.56, P = 0.033; for c.1804C>A: A vs. C, OR = 1.34, 95% CI 1.01–1.77, χ2 = 4.03, P = 0.045). Our results indicate that the XRCC1 c.1161G>A and c.1804C>A genetic polymorphisms significantly influenced the risk of EC in Chinese populations, and might be used as molecular markers for evaluating EC risk.