کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2816164 1159918 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcriptome profile analysis of adipose tissues from fat and short-tailed sheep
ترجمه فارسی عنوان
تجزیه و تحلیل مشخصات ترانسکتروموم از بافت های چربی از گوسفندان چربی و کوتاه دم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی


• We presented the first transcriptome analysis of adipose tissues in sheep.
• Fat deposition in adipose tissues subject to obese and lean meat was evaluated using RNA-seq.
• NELL1 and FMO3 were highlighted as key candidate genes in adipogenesis in sheep.

Recent studies in domestic animals have used RNA-seq to explore the transcriptome of different tissues in a limited number of individuals. In the present study, de novo transcriptome sequencing was used to compare sheep adipose tissue transcriptome profiles between a fat-tailed breed (Kazak sheep; KS) and a short-tailed (Tibetan sheep; TS). The RNA-seq data from these two groups revealed that 646 genes were differentially expressed between the KS and TS groups, including 280 up-regulated and 366 down-regulated genes. We identified genes relevant to fat metabolism in adipose tissues, including two top genes with the largest fold change (NELL1 and FMO3). Pathway analysis revealed that the differentially expressed genes between the KS and TS breeds belong to fatty acid metabolism relevant pathways (e.g. fat digestion and absorption, glycine, serine, and threonine metabolism) and cell junction-related pathways (e.g. cell adhesion molecules) which contribute to fat deposition. This work highlighted potential genes and gene networks that affect fat deposition and meat quality in sheep.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 549, Issue 2, 10 October 2014, Pages 252–257
نویسندگان
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