کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2816209 1159920 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Deletion of CDY1b copy of Y chromosome CDY1 gene is a risk factor of male infertility in Tunisian men
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Deletion of CDY1b copy of Y chromosome CDY1 gene is a risk factor of male infertility in Tunisian men
چکیده انگلیسی


• Determination of CDY1 gene copy deletions in Tunisian infertile men
• Deletion of CDY1b copy gene is a significant risk factor for male infertility.
• Deletion of CDY1a gene seems to have no effect on fertility in Tunisian men.

The relationship between male infertility and microdeletions in the Y chromosome that remove multiple genes varies among countries and populations. The aim of this study was to investigate the different types of Chromodomain protein, Y-linked 1 (CDY1) gene deletions and their effect on male infertility and spermatogenesis in Tunisian men. A total of 241 infertile men with different spermatogenic impairments and 115 fertile men were included in this study. We determined the prevalence of CDY1a and CDY1b copy deletions by PCR-RFLP using PvuII as restriction endonuclease. Results: Among the 356 Tunisian individuals, 93.25% had the two copies (CDY1a and CDY1b) of CDY gene (91.2% in infertile patients and 97.3% in fertile men). We also found that deletion of CDY1b was significantly more frequent in infertile patients (azoo/oligospermic and normospermic) than in fertile men (7% vs 1.7% respectively; p value = 0.02). However, deletion of CDY1a copy was very rare, and was detected in only one fertile man and four normospermic infertile patients. Our findings showed that deletion of CDY1b copy gene is a significant risk factor for male infertility independent of sperm concentration, whereas deletion of CDY1a gene seems to have no effect on fertility in the Tunisian population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 548, Issue 2, 15 September 2014, Pages 251–255
نویسندگان
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