کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2816521 1159939 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
APOBEC2 mRNA and protein is predominantly expressed in skeletal and cardiac muscles of chickens
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
APOBEC2 mRNA and protein is predominantly expressed in skeletal and cardiac muscles of chickens
چکیده انگلیسی


• In this study, we evaluated APOBEC2 mRNA abundance and protein expression and the results indicated that APOBEC2 mRNA was most abundant in skeletal and cardiac muscle.
• Immunoreactive APOBEC2 was localized to the cell nucleus of developing myocardium and skeletal myofibers.
• There were significant differences in mRNA and protein abundance among ages, tissues, and between males and females.

Apolipoprotein B mRNA-editing enzyme catalytic subunit 2 (APOBEC2) plays an important role in regulating and maintaining muscle development in mammals. In this study, we evaluated APOBEC2 mRNA abundance and protein expression and the results indicated that APOBEC2 mRNA was most abundant in skeletal and cardiac muscle, with relatively low expression in the gonads, gizzard and subcutaneous fat tissues of chickens. Immunoreactive APOBEC2 was localized to the cell nucleus of developing myocardium and skeletal myofibers. There were significant differences in mRNA and protein abundance among ages, tissues, and between males and females. In conclusion, APOBEC2 was expressed as the greatest in skeletal muscle and cardiac muscle where it localized to the nucleus. Thus, APOBEC2 may play an important role in muscle development in chickens.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 539, Issue 2, 15 April 2014, Pages 263–269
نویسندگان
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