کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2816904 1159956 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification and genetic effect of haplotype in the bovine BMP7 gene
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Identification and genetic effect of haplotype in the bovine BMP7 gene
چکیده انگلیسی


• The BMP7 singularly promotes differentiation of brown preadipocytes.
• 16 haplotypes were revealed and linkage disequilibrium was assessed in 602 cattle.
• SNP 1, 4 and 5 are associated with the growth traits at 12 and 24 months in NY cattle.
• Bovine BMP7 gene may be utilized as a genetic marker in MAS for beef cattle breeding.

Bone morphogenetic proteins (BMPs) are peptide growth factors belonging to the transforming growth factor-beta (TGF-β) superfamily, and some members of the BMP family support white adipocyte differentiation. In this study, we focused on the BMP7 which singularly promotes the differentiation of brown preadipocytes. Haplotypes involving 5 single nucleotide polymorphism (SNP) sites in the bovine BMP7 gene were identified and their effect on body weight was analyzed. 16 haplotypes and 18 combined haplotypes were revealed and the linkage disequilibrium was assessed in the cattle population with 602 individuals representing three main cattle breeds from China. The results showed that haplotypes 3, 10 and 14 were predominant and accounted for 75.64%, 69.85%, and 83.36% in Nanyang, Qinchuan and Jiaxian cattle breeds, respectively. The statistical analyses indicated that the SNP 1, 4, and 5 are associated with the body weight, body length, and heart girth at 12 and 24 months in Nanyang cattle population (P < 0.05), whereas there is no significant association between their 16 haplotypes and 18 combined haplotypes. Our results provide evidence that some SNPs and haplotypes in BMP7 are associated with growth traits, and may be utilized as a genetic marker in marker-assisted selection for beef cattle breeding programs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 532, Issue 2, 15 December 2013, Pages 281–287
نویسندگان
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