Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants

• Our meta-analyses are involved with 12 variants.
• Our meta-analyses are involved with 23,314 cases and 28,430 controls.
• Meta-analysis among 2538 samples confirmed GPX1 rs1050450 as a CHD risk factor.

AimsThe aim of this study was to evaluate the combined contribution of 12 genetic variants to the risk of coronary heart disease (CHD).MethodsThrough a comprehensive literature search for genetic variants involved in the CHD association study, we harvested a total of 10 genes (12 variants) for the current meta-analyses. These genes consisted of GPX1 (rs1050450), PPARD (rs2016520), ALOX15 (rs34210653), SELPLG (rs2228315), FCGR2A (rs1801274), CCL5 (rs2107538), CYP1A1 (rs4646903), TP53 (rs1042522), CX37 (rs1764391), and PECAM1 (rs668, rs12953, and rs1131012).ResultsA total of 45 studies among 23,314 cases and 28,430 controls were retrieved for the meta-analyses of 12 genetic variants. The results showed a significant association between the GPX1 rs1050450 polymorphism and CHD (odd ratio (OR) = 1.61, 95% confidence interval (CI) = 1.25–2.07, P = 0.0002). Other meta-analyses of the rest 11 variants suggested a lack of association with the risk of CHD.ConclusionOur results confirmed that GPX1 rs1050450 was associated with susceptibility to CHD in Chinese and Indian populations.