کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2817138 | 1159968 | 2013 | 4 صفحه PDF | دانلود رایگان |

• We conducted a hospital-based case–control study among nonsmoking Chinese women.
• We examined three SNPs of PPP1R13L and CD3EAP and lung cancer susceptibility.
• CD3EAP rs967591 variant allele carriers were at increased risk of lung cancer.
• Both D′ values and r2 values accorded with marker distances on chromosome 19q13.3.
• No evidence was found for remaining SNPs and haplotype distributions of three SNPs.
The pathogenesis of lung cancer in the never-smokers could possibly be different from the one in smokers. PPP1R13L and CD3EAP on chromosome 19q13.3 are mainly involved in apoptosis and transcription. PPP1R13L and CD3EAP variants may be associated with cancer risk. We addressed the effects of variants/haplotypes of PPP1R13L rs1970764 and CD3EAP rs967591 and rs735482 on susceptibility of lung cancer among nonsmoking Chinese women. A hospital-based case–control study consisted of 79 lung cancer cases and 108 cancer-free controls matched by age (± 3 years), gender, ethnicity and lifetime never-smoking. Genotyping and statistical analysis were performed by using the method of ligase detection reaction coupled with polymerase chain reaction (LDR–PCR) and SHEsis program and SPSS software. The presence of variant A-allele for CD3EAP rs967591 was associated with increased lung cancer risk [GA versus GG, OR (95% CI) = 2.53 (1.16–5.48), P = 0.02 and GA + AA versus GG, OR (95% CI) = 2.46 (1.16–5.20), P = 0.02]. Both D′ values and r2 values accorded with marker distances on chromosome 19q13.3. No associations were found for two other individual SNPs and haplotype distributions of three markers in the whole or single. In conclusion, this study suggests that CD3EAP rs967591 variant allele carriers are at increased susceptibility of lung cancer among nonsmoking Chinese women.
Journal: Gene - Volume 524, Issue 2, 25 July 2013, Pages 228–231