کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2817509 1159990 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Haplotype distribution in the GLI3 gene and their associations with growth traits in cattle
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Haplotype distribution in the GLI3 gene and their associations with growth traits in cattle
چکیده انگلیسی

The glioma-associated oncogene family zinc finger 3 gene (GLI3) mediates in all vertebrates hedgehog (Hh) signaling that plays an essential role in the induction and patterning of numerous cell types during invertebrate and vertebrate development. In this study, a total of 6 single nucleotide polymorphisms (SNPs: 1–6) were identified by polymerase chain reaction–single stranded conformational polymorphism (PCR–SSCP) and DNA pool sequencing, including all 13 exons and 12 exon–intron boundaries within the bovine GLI3 gene. 16 haplotypes and 13 combined genotypes were revealed and the linkage disequilibrium was assessed in 708 individuals representing three main cattle breeds from China. The statistical analyses indicated that the SNP2, 3 and 4 are associated with the body weight at birth and 6 months in Nanyang cattle population (P < 0.05). No significant association was detected between 11 combined genotypes and body weight at five different ages. Our results provide evidence that polymorphisms in the GLI3 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program.


► The GLI3 plays an essential role in invertebrate and vertebrate development.
► 16 haplotypes were revealed and linkage disequilibrium was assessed in 708 cattle.
► SNP2, 3 and 4 are associated with the body weight at 0 and 6 months in NY cattle.
► A new field of study extends the spectrum of genetic variation of the GLI3 gene.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 513, Issue 1, 15 January 2013, Pages 141–146
نویسندگان
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