کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2817674 | 1160006 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: High expression of miR-210 predicts poor survival in patients with breast cancer: A meta-analysis High expression of miR-210 predicts poor survival in patients with breast cancer: A meta-analysis](/preview/png/2817674.png)
BackgroundMany microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-210 involvement in human breast cancer and analyze the predicting role of miR-210 for survival.MethodsA meta-analysis was performed by searching PubMed, Cochrane Library, and Science Direct databases. Data were extracted from studies comparing survival in patients with breast cancer having higher expression of miR-210 with those having lower expression. Pooled hazard ratios (HRs) and 95% confidence intervals (CI) were calculated.ResultsA total of 511 cases of breast cancer were involved for this global meta-analysis. For post-operational survival, the HR of higher miR-210 expression in breast cancer tissue was 3.39 (95% CI: 2.04–5.63, P < 0.05), which could significantly predict poorer survival.ConclusionsHigh expression of miR-210 might predict poor survival in patients with breast cancer.
► 511 cases of breast cancer were included in this meta-analysis.
► The pooled hazard ratio was 3.39.
► High expression of miR-210 predicts poor survival.
Journal: Gene - Volume 507, Issue 2, 10 October 2012, Pages 135–138