High expression of miR-210 predicts poor survival in patients with breast cancer: A meta-analysis

BackgroundMany microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-210 involvement in human breast cancer and analyze the predicting role of miR-210 for survival.MethodsA meta-analysis was performed by searching PubMed, Cochrane Library, and Science Direct databases. Data were extracted from studies comparing survival in patients with breast cancer having higher expression of miR-210 with those having lower expression. Pooled hazard ratios (HRs) and 95% confidence intervals (CI) were calculated.ResultsA total of 511 cases of breast cancer were involved for this global meta-analysis. For post-operational survival, the HR of higher miR-210 expression in breast cancer tissue was 3.39 (95% CI: 2.04–5.63, P < 0.05), which could significantly predict poorer survival.ConclusionsHigh expression of miR-210 might predict poor survival in patients with breast cancer.

► 511 cases of breast cancer were included in this meta-analysis.
► The pooled hazard ratio was 3.39.
► High expression of miR-210 predicts poor survival.