کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2818341 | 1160045 | 2011 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Characterization of a CENP-B homolog in the holocentric Lepidoptera Spodoptera frugiperda Characterization of a CENP-B homolog in the holocentric Lepidoptera Spodoptera frugiperda](/preview/png/2818341.png)
The discovery of an homolog of the human centromeric protein B, CENP-B, in an EST database of the holocentric insect species Spodoptera frugiperda prompted us to further characterize that gene because i) CENP-B has not been described in invertebrates yet ii) it should be a milestone in the molecular characterization of the holocentric centromere of Lepidoptera.Like its human counterpart, the Sf CENP-B protein is related to the transposase of the pogo transposable element (TE) of D. melanogaster. In this paper, we show evidences that the lepidopteran cenpB gene has evolved from domestication of a transposase. Furthermore, the Sf CENP-B nuclear location and its ability to bind to a retrotransposon derived sequence in vivo argue in favor of a functional homology to CENP-B proteins.
Journal: Gene - Volume 485, Issue 2, 10 October 2011, Pages 91–101