کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2819196 1569910 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds
چکیده انگلیسی

Copy number variants contribute extensively to inter-individual genomic differences, but little is known about their inter-population variability and diversity. In a previous study (Bosch et al., 2007; 16:2572–2582), we reported that the primate-specific gene family FAM90A, which accounts for as many as 25 members in the human reference assembly, has expanded the number of FAM90A clusters across the hominoid lineage. Here we examined the copy number variability of FAM90A genes in 260 HapMap samples of European, African, and Asian ancestry, and showed significant inter-population differences (p < 0.0001). Based on the recent study of Stranger et al. (2007; 315:848–853), we also explored the correlation between copy number variability and expression levels of the FAM90A gene family. Despite the high genomic variability, we found a low correlation between FAM90A copy number and expression levels, which could be due to the action of independent trans-acting factors. Our results show that FAM90A is highly variable in copy number between individuals and between populations. However, this variability has little impact on gene expression levels, thus highlighting the importance of genomic variability for genes located in regions containing segmental duplications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 420, Issue 2, 1 September 2008, Pages 113–117
نویسندگان
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