کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2819561 1569929 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transposable element fragments in protein-coding regions and their contributions to human functional proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Transposable element fragments in protein-coding regions and their contributions to human functional proteins
چکیده انگلیسی

Transposable elements (TEs) and their contributions to protein-coding regions are of particular interest. Here we searched for TE fragments in Homo sapiens at both the transcript and protein levels. We found evidence in support of TE exonization and its association with alternative splicing. Despite recent findings that long evolutionary times are required to incorporate TE into proteins, we found many functional proteins with translated TE cassettes derived from young TEs. Analyses of two Bcl-family proteins and Alu-encoded segments suggest the coding and functional potential of TE sequences.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 401, Issues 1–2, 15 October 2007, Pages 165–171
نویسندگان
, , ,