کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2819848 1569938 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selective inhibition of Alu retrotransposition by APOBEC3G
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Selective inhibition of Alu retrotransposition by APOBEC3G
چکیده انگلیسی

The non-LTR retrotransposon LINE-1 (L1) comprises ∼ 17% of the human genome, and the L1-encoded proteins can function in trans to mediate the retrotransposition of non-autonomous retrotransposons (i.e., Alu and probably SVA elements) and cellular mRNAs to generate processed pseudogenes. Here, we have examined the effect of APOBEC3G and APOBEC3F, cytidine deaminases that inhibit Vif-deficient HIV-1 replication, on Alu retrotransposition and other L1-mediated retrotransposition processes. We demonstrate that APOBEC3G selectively inhibits Alu retrotransposition in an ORF1p-independent manner. An active cytidine deaminase site is not required for the inhibition of Alu retrotransposition and the resultant integration events lack G to A or C to T hypermutation. These data demonstrate a differential restriction of L1 and Alu retrotransposition by APOBEC3G, and suggest that the Alu ribonucleoprotein complex may be targeted by APOBEC3G.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 390, Issues 1–2, 1 April 2007, Pages 199–205
نویسندگان
, , , ,