کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2836868 1164863 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biomarker evaluation as a potential cause of gender differences in obesity paradox among patients with STEMI
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
Biomarker evaluation as a potential cause of gender differences in obesity paradox among patients with STEMI
چکیده انگلیسی


• Higher risk for MACE was shown in group BMI ≤ 24.9 kg/m2 compared to BMI 25.0–29.9 kg/m2.
• The study showed no association between HDL-c (p = 0.55) or LDL-c (p = 0.10) and MACE.
• No gender difference between MACE and BMI could be detected (p = 0.16).

BackgroundObesity with its worldwide growing prevalence is an established cardiovascular risk factor with increased morbidity and mortality. However, the phenomenon, that mild to moderate obesity seems to represent a protective effect on diseases has been termed the “obesity paradox”.MethodsWe retrospectively assessed 529 patients (72.6% male, mean age 59.7 ± 12.7 years) admitted with ST-elevation myocardial infarction (STEMI). The female and male study populations were separated into four body mass index (BMI) groups: ≤ 24.9 kg/m2, 25.0–29.9 kg/m2, 30.0–34.9 kg/m2 and ≥ 35.0 kg/m2. Blood samples of high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were analyzed.ResultsWith increasing BMI group the rate of major adverse cardiac events (MACE) decreased in all patients (test for trend p = 0.041). No gender difference between MACE and BMI could be noticed (p = 0.16). A higher risk for MACE was indicated in group BMI ≤ 18.5 kg/m2 in comparison to group BMI 25.0–29.9 kg/m2 (OR: 7.93; 95% CI: 1.75–35.89; p = 0.0091), whereas group BMI 30.0–34.9 kg/m2 was significant associated with a lower risk in comparison to group BMI 25.0–29.9 kg/m2 (OR: 0.65; 95% CI: 0.21–1.96; p = 0.044). An association between HDL-c (p = 0.55) or LDL-c (p = 0.10) and MACE could not be detected.ConclusionThe study demonstrates that patients with STEMI and a BMI of 30.0–34.9 kg/m2 have a decreased risk for MACE compared to patients with normal BMI. No gender related differences were indicated. An association between MACE and lipoproteins could not be detected.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cardiovascular Revascularization Medicine - Volume 17, Issue 2, March 2016, Pages 88–94
نویسندگان
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