کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2837107 1164888 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of short-term anti-inflammatory therapy on endothelial function in patients with non-ST-segment elevation acute coronary syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
Effects of short-term anti-inflammatory therapy on endothelial function in patients with non-ST-segment elevation acute coronary syndrome
چکیده انگلیسی

The aim was to assess the impact of the short-term anti-inflammatory therapy on coronary endothelial function in non-ST-segment elevation acute coronary syndrome patients. In 30 patients, coronary endothelial function was assessed by acetylcholine test. Vessel response was calculated as a percent change of mean lumen diameter (MLD). Then patients were randomized into three groups: A (n=11) placebo, B (n=11) 80 mg atorvastatin, C (n=8) 80 mg atorvastatin and 25 mg rofecoxib. After 7 days control test was performed. Recovery of coronary endothelial function was calculated as delta in percent changes of MLD between Days 1 and 7. On Day 1, percent change of MLD between baseline and maximum acetylcholine did not differentiate the groups: −20±3.5% in A, −25±3.9% in B and −26±3.7% in C, P=.20. On Day 7, percentage changes in MLD were as follows: −21±3.9% in A, −15±3.0% in B and −10±4.0% in C, P=.002. The delta in percentage change in MLD between Days 1 and 7 were as follows: −1% in A, + 10% in B and +16% in C, P=.02. In conclusion, short-term, anti-inflammatory therapy with high-dose atorvastatin and selective cyclooxygenase-2 inhibitor improves coronary endothelial function within 7 days in non-ST-segment elevation acute coronary syndrome patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cardiovascular Revascularization Medicine - Volume 12, Issue 1, January–February 2011, Pages 2–9
نویسندگان
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