Resolute zotarolimus-eluting stent to treat bifurcated lesions according to the provisional technique: A procedural performance comparison with sirolimus- and everolimus-eluting stents

ObjectivesDifferent drug-eluting stents (DES) may have different performance in bifurcation PCI. Thus, we compared the performance of a novel zotarolimus-eluting stent (ZRS) with that obtained using two other DES in bifurcation PCI.Methods and ResultsConsecutive patients with bifurcated lesions undergoing DES implantation were treated by a provisional approach with sirolimus-eluting stent (SES) or everolimus-eluting stent (EES) during a former period, and then by ZRS in a second period. The PCI procedural details were prospectively recorded and angiographic results were evaluated by a 3-dimensional quantitative coronary analysis software. Primary procedural end-point was “side-branch (SB) trouble” (occurrence, after MV stenting, of: SB TIMI flow < 3 or need of specific wires for SB rewiring, or failure to re-wire/dilate the SB). Primary angiographic end-point was post-PCI minimal-lumen-diameter at SB-ostium.During the study, 225 patients were enrolled and treated by ZRS (n = 75), by SES (n = 75) or by EES (n = 75). Among procedural characteristics, “SB trouble” occurred in 4% of patients treated by ZRS, a figure significantly lower compared to SES (16%, P = 0.014) and non-significantly lower compared to EES (11%, P = 0.12). At multivariable analysis, DES type, pre-PCI SB flow < 3 and bifurcation complexity were the only predictors of “SB trouble”.After the procedure, minimal-lumen-diameter at SB ostium was significantly larger with ZRS compared to SES (1.94 vs. 1.64 mm, P = 0.008) and similar to that of EES.ConclusionsZRS is associated to improved performance and SB angiographic results compared to SES. These results support the hypothesis that DES selection may influence the procedural course and the acute angiographic result of bifurcation PCI.