کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2837653 | 1164904 | 2009 | 4 صفحه PDF | دانلود رایگان |

BackgroundRecurrent disease (restenosis) after endovascular treatment of the superficial femoral artery (SFA) remains a major problem. We evaluated the efficacy of beta-endovascular brachytherapy using the CORONA centering catheter in patients with SFA restenosis in a single-arm Phase II trial.Methods and resultsA total of 28 patients (mean age 70 years; 16 female, 12 male) with recurrent SFA stenosis were treated, and in-stent restenosis was present in 17 patients (61%). Brachytherapy was performed with strontium-90 beta source using a 7-French CO2-filled one-segment centering catheter. New stents had to be applied in two cases. Mean interventional length was 129 mm (range 20–240 mm). A dose of 14 Gy in vessel radius (postinterventional) plus 2 mm was applied in 24 patients and 18.4 Gy in four patients. Treatment time was 7 min 32 s per radiation segment. No major adverse events occurred. Patients were followed by ankle-brachial index and duplex sonography for a median of 42 months. Cumulative restenosis rates at 1, 2, and 3 years were 9%, 28%, and 40%, respectively. Target vessel revascularization was performed in seven cases (25%).ConclusionsIn comparison to literature data, the treatment of SFA restenosis with beta brachytherapy may improve long-term patency.
Journal: Cardiovascular Revascularization Medicine - Volume 10, Issue 3, July–September 2009, Pages 162–165