کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2838532 | 1165023 | 2014 | 6 صفحه PDF | دانلود رایگان |
• Diabetic foot ulcers (DFUs) are a major complication of diabetes.
• We describe the development of next-generation technologies for DFU repair.
• We highlight the modest success of growth factor-, scaffold-, and cell-based DFU therapies.
• We rationalize that combination therapies will be necessary to enable effective and reliable DFU repair.
Type 2 diabetes is the epidemic of our generation, and diabetic foot ulcers (DFUs) are a major complication. Although DFU formation itself can indicate disease progression, the failure to effectively treat ulcers contributes further to a decay in patient quality of life and increased mortality. Herein we discuss the development of next-generation DFU therapies including: (i) topical growth factors, (ii) scaffolds, and (iii) cellular therapies. Individually these therapies have yielded measurable but modest improvements in DFU repair. Because DFUs arise as a result of multiple biochemical deficiencies, a singular treatment modality is unlikely to be effective. Next-generation DFU technologies must be combined to address effectively the complex underlying pathology and enable reliable DFU repair.
Journal: - Volume 20, Issue 3, March 2014, Pages 137–142