Gating pluripotency via nuclear pores

• Dynamic nuclear transport in pluripotency maintenance and cell differentiation.
• Trafficking of pluripotency factors through nuclear pores.
• Nuclear pore dysfunction in human diseases and aging is discussed.
• Cell fate and nuclear pore activity.

In recent years, growing evidence has pointed to the interesting idea that pluripotency might be regulated by a nuclear-pore-coordinated network that controls the level of pluripotency factors in the nucleus. A thorough understanding of this process might improve our comprehension of cell pluripotency and differentiation during embryogenesis, as well as aiding the development of novel models for studying human diseases.