کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2838684 1165041 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does steroid sulfatase deficiency influence postpartum psychosis risk?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
Does steroid sulfatase deficiency influence postpartum psychosis risk?
چکیده انگلیسی

Postpartum (or puerperal) psychosis (PP) occurs shortly after childbirth in 0.1–0.2% of women, and is characterised by delusions, mood swings, confused thinking, and disorganised behaviour. The condition is disturbing for patients and their family members and loved ones, and affected individuals may be at increased risk of harming themselves or their offspring. The features of PP indicate a substantial biological basis to its pathogenesis, although currently little is known about possible risk factors. Based on recent results from animal model and human studies, I propose that reduced function of the enzyme steroid sulfatase in the mother represents a unifying and physiologically plausible candidate mechanism for the neural and endocrinological disturbances seen in cases of PP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 18, Issue 5, May 2012, Pages 256–262
نویسندگان
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