کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2838693 | 1165042 | 2013 | 13 صفحه PDF | دانلود رایگان |

• PDGF-C promotes blood vessel growth and maturation.
• PDGF-C is a potent survival factor for different types of neurons.
• The expression and function of PDGF-C and its receptors differ from those of VEGF.
• PDGF-C may represent a new paradigm of neurovascular interaction and crosstalk.
The importance of neurovascular crosstalk in development, normal physiology, and pathologies is increasingly being recognized. Although vascular endothelial growth factor (VEGF), a prototypic regulator of neurovascular interaction, has been studied intensively, defining other important regulators in this process is warranted. Recent studies have shown that platelet-derived growth factor C (PDGF-C) is both angiogenic and a neuronal survival factor, and it appears to be an important component of neurovascular crosstalk. Importantly, the expression pattern and functional properties of PDGF-C and its receptors differ from those of VEGF, and thus the PDGF-C-mediated neurovascular interaction may represent a new paradigm of neurovascular crosstalk.
Journal: - Volume 19, Issue 8, August 2013, Pages 474–486