کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2838693 1165042 2013 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PDGF-C: a new performer in the neurovascular interplay
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
PDGF-C: a new performer in the neurovascular interplay
چکیده انگلیسی


• PDGF-C promotes blood vessel growth and maturation.
• PDGF-C is a potent survival factor for different types of neurons.
• The expression and function of PDGF-C and its receptors differ from those of VEGF.
• PDGF-C may represent a new paradigm of neurovascular interaction and crosstalk.

The importance of neurovascular crosstalk in development, normal physiology, and pathologies is increasingly being recognized. Although vascular endothelial growth factor (VEGF), a prototypic regulator of neurovascular interaction, has been studied intensively, defining other important regulators in this process is warranted. Recent studies have shown that platelet-derived growth factor C (PDGF-C) is both angiogenic and a neuronal survival factor, and it appears to be an important component of neurovascular crosstalk. Importantly, the expression pattern and functional properties of PDGF-C and its receptors differ from those of VEGF, and thus the PDGF-C-mediated neurovascular interaction may represent a new paradigm of neurovascular crosstalk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 19, Issue 8, August 2013, Pages 474–486
نویسندگان
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