کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2838860 1165059 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulatory T cells in CNS injury: the simple, the complex and the confused
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
Regulatory T cells in CNS injury: the simple, the complex and the confused
چکیده انگلیسی

Regulatory CD4+CD25+Foxp3+ T cells (Tregs) have been the focus of significant attention for their role in controlling immune responses. Although knowledge of Treg biology has burgeoned, wide gaps remain in our understanding of Treg function under both normal and pathological conditions. Pioneering studies demonstrated roles for Tregs in cancer and autoimmune diseases, including experimental autoimmune encephalitis, and this knowledge is often applied to other pathologies including neurodegenerative conditions. However, differences between immunity in neurodegeneration and in malignancy or autoimmunity are often neglected. Thus, Treg manipulations in central nervous system (CNS) neurodegenerative conditions often yield unexpected outcomes. In this piece, we explore how the immunology of neurodegeneration differs from that of cancer and autoimmunity and how these differences create confusion about the role of Tregs in neurodegenerative conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 10, October 2011, Pages 541–547
نویسندگان
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