کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2838865 1165059 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enterocyte death and intestinal barrier maintenance in homeostasis and disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
Enterocyte death and intestinal barrier maintenance in homeostasis and disease
چکیده انگلیسی

The intestinal epithelium is the largest surface area of the body in contact with the external environment. This specialized single cell layer is constantly renewed and is a physical barrier that separates intestinal microbiota from underlying tissues, preventing bacterial infiltration and subsequent inflammation. Specialized secretory epithelial cell types such as Paneth cells and goblet cells limit bacterial adhesion and infiltration by secreting antibacterial peptides and mucins, respectively. Rapid cell renewal coincides with apical exfoliation of ‘old’ enterocytes without compromising epithelial barrier integrity. When the intestinal epithelium is inflamed barrier integrity can be compromised, due to uncontrolled death of enterocytes allowing bacterial infiltration. This review discusses the different mechanisms which regulate or affect intestinal barrier integrity under homeostatic and inflammatory conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 10, October 2011, Pages 584–593
نویسندگان
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