کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2839048 1165078 2010 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular pathways regulating CD4+ T cell differentiation, anergy and memory with implications for vaccines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
Molecular pathways regulating CD4+ T cell differentiation, anergy and memory with implications for vaccines
چکیده انگلیسی

CD4+ T cells occupy a central role in the induction and regulation of adaptive immune responses. Activated CD4+ T helper (Th) cells exert immediate effector functions by producing cytokines and chemokines, providing help for the induction of CD8+ cytotoxic T lymphocyte responses and memory, and providing help for immunoglobulin class switching, affinity maturation of antibody and B cell memory. Inherent in naïve CD4+ T cells is the flexibility to adopt alternate lineage potentials, which depend upon regulatory mechanisms that change with tissue microenvironment and upon infection. Here, we discuss lineage instructive programs that regulate CD4+ T cell differentiation and memory and how to translate this knowledge into vaccines and immunotherapies that promote protective immune responses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 16, Issue 10, October 2010, Pages 478–491
نویسندگان
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