کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2839201 1165095 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New insights into the pathophysiology of cobalamin deficiency
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
New insights into the pathophysiology of cobalamin deficiency
چکیده انگلیسی

Cobalamin-deficient (Cbl-D) central neuropathy in the rat is associated with a locally increased expression of neurotoxic tumour necrosis factor-α (TNF-α) and a locally decreased expression of neurotrophic epidermal growth factor (EGF). These recent findings suggest that cobalamin oppositely regulates the expression of TNF-α and EGF, and raise the possibility that these effects might be independent of its coenzyme function. Furthermore, adult Cbl-D patients have high levels of TNF-α and low levels of EGF in the serum and cerebrospinal fluid. Serum levels of TNF-α and EGF of cobalamin-treated patients normalize concomitantly with haematological disease remission. These observations suggest that cobalamin deficiency induces an imbalance in TNF-α and EGF levels in biological fluids that might have a role in the pathogenesis of the damage caused by pernicious anaemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 12, Issue 6, June 2006, Pages 247–254
نویسندگان
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