کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2839258 1165101 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MHC–peptide specificity and T-cell epitope mapping: where immunotherapy starts
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
MHC–peptide specificity and T-cell epitope mapping: where immunotherapy starts
چکیده انگلیسی

The evaluation and characterization of epitope-specific human leukocyte antigen (HLA)-restricted memory T-cell reactivity is an important step for the development of preventive vaccines and peptide-based immunotherapies for viral and tumor diseases. The past decade has witnessed the use of HLA-restricted peptides as tools to activate strong immune responses of naïve or memory T cells specifically. This has fuelled an active search for methodological approaches focusing on HLA and peptide associations. Here, we outline new perspective on the emerging opportunity of evaluating HLA and peptide restriction by using novel approaches, such as quantitative real-time PCR, that can identify epitope specificities that are potentially useful in clinical settings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 12, Issue 10, October 2006, Pages 465–472
نویسندگان
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