کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2839387 1165122 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Estrogen receptors: new players in diabetes mellitus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
Estrogen receptors: new players in diabetes mellitus
چکیده انگلیسی

Diabetes mellitus type 2 is a systemic disease characterized by imbalance of energy metabolism, which is mainly caused by inadequate insulin action. Recent data have revealed a surprising role for estradiol in regulating energy metabolism and opened new insights into the role of the two estrogen receptors, ERα and ERβ, in this context. New findings on gene modulation by ERα and ERβ of insulin-sensitive tissues indicate that estradiol participates in glucose homeostasis by modulating the expression of genes that are involved in insulin sensitivity and glucose uptake. Drugs that can selectively modulate the activity of either ERα or ERβ in their interactions with target genes represent a promising frontier in diabetes mellitus coadjuvant therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 12, Issue 9, September 2006, Pages 425–431
نویسندگان
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