کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2839388 1165122 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation-induced deaminase: light and dark sides
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
Activation-induced deaminase: light and dark sides
چکیده انگلیسی

Activation-induced deaminase (AID) is required for class switch recombination (CSR) and somatic hypermutation (SHM), which are responsible for secondary diversification of antibodies in germinal centers. AID initiates these processes by deamination of cytosines on the immunoglobulin (Ig) locus, a potentially mutagenic activity. AID expression is restricted to germinal-center B cells, but the mechanisms that regulate its target specificity are not completely understood. Here, we review the most recent findings on the regulation of AID targeting and discuss how AID activity on non-Ig genes is relevant to the generation of chromosome translocations and to lymphomagenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 12, Issue 9, September 2006, Pages 432–439
نویسندگان
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