کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2840559 | 1165331 | 2013 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Insect immune system maintains long-term resident bacteria through a local response Insect immune system maintains long-term resident bacteria through a local response](/preview/png/2840559.png)
Long-term associations between bacteria and animals are widely represented in nature and play an important role in animal adaptation and evolution. In insects thriving on nutritionally unbalanced diets, intracellular symbiotic bacteria (endosymbionts) complement the host nutrients with amino acids and vitamins and interfere with host physiology and reproduction. Endosymbionts permanently infect host cells, called bacteriocytes, which express an adapted local immune response that permits symbiont maintenance and control. Among the immune players in bacteriocytes, the coleoptericin A (ColA) antimicrobial peptide of the cereal weevil, Sitophilus zeamais, was recently found to specifically trigger endosymbionts and to inhibit their cytokinesis, thereby limiting bacterial cell division and dispersion throughout the insect tissues. This review focuses on the biological and evolutionary features of Sitophilus symbiosis, and discusses the possible interactions of ColA with weevil endosymbiont proteins and pathways.
Figure optionsDownload as PowerPoint slideHighlights
► Insect immune system perceives endosymbiotic bacteria.
► Symbiont maintenance and control via a specific local immune response.
► The antimicrobial peptide coleoptericin A hampers bacterial cells division.
Journal: Journal of Insect Physiology - Volume 59, Issue 2, February 2013, Pages 232–239