کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2843910 1571156 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Angiotensin II (de)sensitization: Fluid intake studies with implications for cardiovascular control
ترجمه فارسی عنوان
حساس سازی(حساس زدایی)آنژیوتانسین II: مطالعات مصرف مایعات با پیامدهای کنترل قلب و عروق
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
چکیده انگلیسی


• Hypertension and cardiovascular disease are growing health concerns.
• Improper fluid balance is an underlying factor in hypertension.
• Drinking induced by angiotensin II (AngII) is an important model system.
• Repeated “pulsed” injections of AngII cause rapid desensitization.
• Pulsed injections appear to counteract the sensitizing effect of chronic AngII.

Cardiovascular disease is the leading cause of death worldwide and hypertension is the most common risk factor for death. Although many anti-hypertensive pharmacotherapies are approved for use in the United States, rates of hypertension have increased over the past decade. This review article summarizes a presentation given at the 2015 meeting of the Society for the Study of Ingestive Behavior. The presentation described work performed in our laboratory that uses angiotensin II-induced drinking as a model system to study behavioral and cardiovascular effects of the renin-angiotensin system, a key component of blood pressure regulation, and a common target of anti-hypertensives. Angiotensin II (AngII) is a potent dipsogen, but the drinking response shows a rapid desensitization after repeated injections of AngII. This desensitization appears to be dependent upon the timing of the injections, requires activation of the AngII type 1 (AT1) receptor, requires activation of mitogen-activated protein (MAP) kinase family members, and involves the anteroventral third ventricle (AV3V) region as a critical site of action. Moreover, the response does not appear to be the result of a more general suppression of behavior, a sensitized pressor response to AngII, or an aversive state generated by the treatment. More recent studies suggest that the treatment regimen used to produce desensitization in our laboratory also prevents the sensitization that occurs after daily bolus injections of AngII. Our hope is that these findings can be used to support future basic research on the topic that could lead to new developments in treatments for hypertension.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 162, 1 August 2016, Pages 141–146
نویسندگان
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