Diaphragmatic fatigue during inspiratory muscle loading in normoxia and hypoxia

• We investigated the effect of hypoxia on the progression of diaphragmatic fatigue during inspiratory muscle loading.
• In normoxia the progression of diaphragmatic fatigue during inspiratory muscle loading follows an exponential decay.
• In hypoxia the progression of diaphragmatic fatigue during inspiratory muscle loading follows a linear decline.

IntroductionDiaphragmatic fatigue (DF) occurs during strenuous loading of respiratory muscles (e.g., heavy-intensity whole-body exercise, normocapnic hyperpnea, inspiratory resistive breathing). DF develops early on during normoxia, without further decline toward task failure; however, its progression during inspiratory muscle loading in during hypoxia remains unclear. Therefore, the present study used volume-corrected transdiaphragmatic pressures during supramaximal magnetic phrenic nerve stimulation (Pdi,twc) to investigate the effect of hypoxia on the progression of diaphragmatic fatigue during inspiratory muscle loading.MethodsSeventeen subjects completed two standardized rounds of inspiratory muscle loading (blinded, randomized) under the following conditions: (i) normoxia, and (ii) normobaric hypoxia (SpO2 80%), with Pdi,twc assessment every 45s.ResultsIn fatiguers (i.e., Pdi,twc reduction >10%, n = 10), biometric approximation during normoxia is best represented by Pdi,twc = 4.06 + 0.83 exp(−0.19 × x), in contrast to Pdi,twc = 4.38 − (0.05 × x) during hypoxia.ConclusionProgression of diaphragmatic fatigue during inspiratory muscle loading assessed by Pdi,tw differs between normoxia and normobaric hypoxia: in the former, Pdi,tw follows an exponential decay, whereas during hypoxia, Pdi,tw follows a linear decline.