کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2846973 1571327 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Keratinocyte growth factor-2 is protective in lipopolysaccharide-induced acute lung injury in rats
ترجمه فارسی عنوان
عامل رشد کراتینوسیت 2 در موشهای صحرایی آسیب ریه حاد ناشی از لیپوپلی ساکارید محافظت می کند
کلمات کلیدی
آسیب ریه حاد عامل رشد کراتینوسیت-2، لیپوپلی ساکارید، سلولهای اپیتلیال، پروتئین سورفکتانت ریوی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
چکیده انگلیسی


• Intratracheal KGF-2 attenuated lipopolysaccharide-induced lung injury in rats.
• KGF-2 given 2–3 days before LPS challenge showed maximum improvement.
• KGF-2 pretreatment restored synthesis of pulmonary surfactant protein A and C.
• KGF-2 stimulated hyperplasia of alveolar type II epithelial cells.

Keratinocyte growth factor-2 (KGF-2) plays a key role in lung development, but its role in acute lung injury has not been well characterized. Lipopolysaccharide instillation caused acute lung injury, which significantly elevated lung wet-to-dry weight ratio, protein and neutrophils in bronchoalveolar lavage fluid (BALF), inhibited surfactant protein A and C expression in lung tissue, and increased pathological injury. Pretreatment with KGF-2 improved the above lung injury parameters, partially restored surfactant protein A and C expression, and KGF-2 given 2–3 days before LPS challenge showed maximum lung injury improvement. Pretreatment with KGF-2 also markedly reduced the levels of TNF-α, MIP-2, IL-1β and IL-6 in BALF and the levels of IL-1β and IL-6 in lung tissue. Histological analysis showed there was increased proliferation of alveolar type II epithelial cells in lung parenchyma, which reached maximal 2 days after KGF-2 instillation. Intratracheal administration of KGF-2 attenuates lung injury induced by LPS, suggesting KGF-2 may be potent in the intervention of acute lung injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 201, 15 September 2014, Pages 7–14
نویسندگان
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