کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2847117 | 1571338 | 2014 | 6 صفحه PDF | دانلود رایگان |
• Healthy subjects and patients suffering from mitochondrial myopathy underwent brachial artery occlusion.
• Muscle (de)oxygenation (oxy[Hb+Mb] and deoxy[Hb+Mb] was registered with NIRS during and following occlusion.
• The kinetics of deoxy[Hb+Mb] were slower in patients during occlusion.
• The kinetics of oxy[Hb+Mb] were faster compared to deoxy[Hb+Mb] in both groups, resulting in a transient increase in total[Hb+Mb].
• The kinetics of both oxy[Hb+Mb] and deoxy[Hb+Mb] were faster in patients compared to healthy subject post occlusion.
The aim was to study whether mitochondrial myopathy induces different oxygenation (deoxy[Hb+Mb] and oxy[Hb+Mb]) responses during and following arterial occlusion. In 10 mitochondrial myopathy patients (MMpatients) (age: 29 ± 7 years; body mass: 59.9 ± 15.7 kg; heigth: 166.2 ± 11.4 cm) and age- and gender-matched healthy subjects (age: 28 ± 9 years; body mass: 72.7 ± 16.9 kg; height: 174.4 ± 8.7 cm) arterial occlusion was performed by inflating a cuff to 240 mmHg. Deoxy[Hb+Mb] and oxy[Hb+Mb] were registered during (AOoxy and AOdeoxy) and following (POdeoxy and POoxy) arterial occlusion. Amplitude of AOdeoxy did not differ (p = 0.47) between MMpatients (44.9 ± 28.0 μM) and healthy subjects (38.6 ± 22.8 μM), The time constant of the exponential model was greater in MMpatients (263.4 ± 49.1 s vs. 200.3 ± 73.7 s, p = 0.03). Following cuff release, in both populations a transient increase in total[Hb+Mb] was observed induced by different kinetics of POoxy and POdeoxy. The increase in POoxy (TD = 6.6 ± 2.2 s and 11.9 ± 3.5 s; τ = 3.8 ± 1.4 s and 6.4 ± 2.9 s for MMpatients and healthy subjects, respectively) was faster (p < 0.001 for TD and τ) compared to the decrease in POdeoxy (TD = 13.2 ± 3.6 s and 26.5 ± 4.6 s; τ = −6.2 ± 2.2 s and −9.6 ± 2.4 s for MMpatients and healthy subjects, respectively). POoxy and POdeoxy showed faster kinetics (p < 0.001 and p < 0.01 for TD and τ, respectively) in MMpatients compared to healthy subjects. MMpatients display altered oxygenation responses during and following arterial occlusion reflecting pathology related changes in the relationship between muscle blood flow and oxygen uptake.
Journal: Respiratory Physiology & Neurobiology - Volume 190, 1 January 2014, Pages 70–75