کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2847212 | 1167342 | 2013 | 9 صفحه PDF | دانلود رایگان |
Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case–control study explores the possibility that sleep-disordered breathing (SDB) and associated oxidative stress contribute to the etiology of CMS. Nocturnal respiratory and SaO2SaO2 patterns were measured using standard polysomnography techniques and compared between male high-altitude residents (aged 18–25) with preclinical CMS (excessive erythrocytosis (EE), n = 20) and controls (n = 19). Measures of oxidative stress and antioxidant status included isoprostanes (8-iso-PGF2alpha), superoxide dismutase and ascorbic acid. EE cases had a greater apnea–hypopnea index, a higher frequency of apneas (central and obstructive) and hypopneas during REM sleep, and lower nocturnal SaO2SaO2 compared to controls. 8-iso-PGF2alpha was greater in EE than controls, negatively associated with nocturnal SaO2SaO2, and positively associated with hemoglobin concentration. Mild sleep-disordered breathing and oxidative stress are evident in preclinical CMS, suggesting that the resolution of nocturnal hypoxemia or antioxidant treatment may prevent disease progression.
► We explore the role of sleep-disordered breathing and oxidative stress for polycythemia (CMS).
► Mild sleep-disordered breathing and oxidative stress are evident prior to CMS.
► The resolution of nocturnal hypoxemia or antioxidant therapy may prevent the progression of CMS.
Journal: Respiratory Physiology & Neurobiology - Volume 186, Issue 2, 1 April 2013, Pages 188–196